Thanks. It seems like a good project, but:
Be advised: Due to the way that the Survival & Flourishing Fund does speculation grants, it is in some respects advantageous to your application if you apply far away from a round's deadline. E.g. right now.
https://survivalandflourishing.fund
I was a Recommender in a past Theme Round & I'm currently a speculation grantor. Some projects I'd be interested in making speculation grants to (though note that I'm not currently scheduled to be a Recommender in any round): https://lesswrong.com/posts/MBxSbzYECJEoeTkwZ/sff-s-hsee-grant-round-human-intelligence-amplification
In particular, I'm interested in reprogenetics: https://reprogeneticsinstitute.org/articles/Projects_that_might_help_accelerate_strong_reprogenetics.html
(Feel free to reach out to me if you have a relevant project.)
thousands of very smart people put in lots of effort to apply, and the org says "Oh no, not any of you guys"
(I'll note that I'm qualified to be a grantmaker for the area of human intelligence amplification, which many leaders in AI safety view as a crucial second or third priority behind "stop AI" and "at least try to solve alignment". But it seems like a waste of my time to apply to be a grantmaker at CG without some indication that they'd be open to this. I did message a couple people hoping for a quick "nah" or "worth applying" but didn't hear back.)
As a first draft, roughly, I think the speculation is worthwhile IF AND ONLY IF it's in a context where it will then be followed up by maker/breaker investigation, on the question of "whether / how this can actually lead to SHIA in the real world". This includes going back and forth between skeptically searching for flaws, and optimistically searching for workarounds/alternatives/reasons for hope. It also includes thinking about the whole process of getting to the working tech, including
You're talking about revascularization? It's interesting, but would need a lot of fleshing out.
To step back a bit, I appreciate you thinking about these things and proposing ideas, but in order to make something actually work, I think there has to be a lot more in depth exploration. In particular, there'd have to be iterative maker/breaker investigation of the idea. In other words, I think you should argue against your own idea, then improve the idea and counterargue in favor, then critique the new version again, and repeat. Then for some ideas, you might actually convince yourself that the idea isn't that workable or promising; for other ideas, you might be able to make a more convincing case and/or put together a promising version of the project.
At the moment I don't know much about what other funders there might be for something like this, sorry. I might know more in several months, though this type of thing is out of my wheelhouse.